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7/11/2008

'DNA computer' is unbeatable at tic-tac-toe

A computer that uses strands of DNA to perform calculations has mastered the game tic-tac-toe.

MAYA-II, developed by researchers at Columbia University and the University of New Mexico in the US, uses a system of DNA logic gates to calculate its moves.

A DNA logic gate consists of a strand of DNA that binds to another specific input sequence. This binding causes a region of the strand to work as an enzyme, modifying yet another short DNA sequence into an output string.

Scientists have already developed DNA computers capable of various similar simple calculations. But the researchers behind MAYA-II say their design should prove particularly useful for exploring ways to identify the genetic markers associated with certain diseases.

Another level

A human plays MAYA-II by adding a DNA sequence that represents their chosen move at a particular point in the game. This is added to all 8 wells that correspond to the outer squares on a tic-tac-toe grid. One limitation of the system is that the human player must always go second, after the centre square has been filled by the machine.

The previous version of MAYA, unveiled in 2003, was even more limited. The human opponent’s first move was restricted to one of two squares (see First game-playing DNA computer revealed).

Each well contains between 14 and 18 DNA logic gates. After a human player makes their move, MAYA-II responds through a DNA reaction. The strand outputted feeds into a series of other DNA logic gates that link the different wells. This results in a chemical reaction that generates a green fluorescent glow in the square MAYA-II selects as its next move. The strand also interacts with the remaining wells, priming them to respond appropriately to future moves.

"MAYA-II moves bio-computation up to the next level of power," says Joanne Macdonald, a researcher at Columbia University, who helped build the system. "It's similar to the invention of the first microchips with hundreds of logic gates."

Right direction

"Those kind of experiments are the right direction for DNA computation," says Martyn Amos, an expert at Manchester Metropolitan University in the UK. But he adds that, "it's not something you can pit against silicon".

"Playing with MAYA-II takes a long time," Macdonald admits. The system needs between 2 and 30 minutes to compute each move and a second machine is required to translate the fluorescent signals generated each time into a move in the game.

However, Macdonald believes the technique could help researchers refine techniques for analysis of DNA samples. She is already using DNA logic gates to separate viruses and detect particular combinations of DNA mutations.

Amos agrees that MAYA-II could help researchers in this way. But he warns that the DNA molecules used cannot be controlled perfectly, and could be prone to the occasional malfunction.

Tom Simonite

Tech News & Notes

DESKTOPS & LAPTOPS


MSI’s new Wind isn’t merely a carbon copy of the Asus Eee PC, but instead a legitimate contender to the mini-notebook crown, thanks to its impressive horsepower and affordable price.

Mini-Notebook Arena Gets A Gust Of Wind

If the commotion over the Asus Eee PC hasn’t swayed you to consider dumping your big, bulky laptop for a miniature version, perhaps the new MSI Wind will. Although the Eee delivers plenty of performance for a great price, the Wind could be an even better bargain.

As discussed in recent issues, the original, low-priced Eee earned praise, but Asus has slowly raised prices on successive models. MSI’s Wind has launched at $399 in its base form, and, like Asus, MSI offers more powerful versions at higher prices.

But even for the relatively affordable base price, the Wind offers plenty of punch, with a 10-inch display with 1,024 x 600 resolution, 80GB hard drive, 512MB of RAM, and a 3-cell battery. This base model runs Novell’s SUSE Linux, but if you want Windows XP, you’ll need to shell out $549 for an upgraded Wind with an 80GB hard drive, 1GB of RAM, a 6-cell battery, and Bluetooth. Both versions will use Intel’s next-generation Atom 1.6GHz processor.

In addition to the relatively large display, the Wind also features a roomy keyboard, with MSI enlarging the gaps between the keys to 17.5mm for better ergonomics, resulting in a keyboard that could compare favorably with those on larger notebooks. However, these larger components result in a device that is slightly larger than the Eee. While the different versions of the Eee weigh just around 2 pounds, the $399 Wind weighs 2.3 pounds, and the $549 Wind weighs....

How to Make Sales 24 Hours A Day, 7 Days A Week

For years now, I've been playing a game with my kids. It's called "Guess What Daddy's Doing!" and it goes like this:

I could be at a restaurant with my family, at a basketball game, driving down the road, standing in line somewhere, laying on the couch, or playing a video game (I'm a big 'Rock Band' fan). Sometimes, I might actually be working!

Every once in a while, without warning, I'll turn to one of the kids and say, "Hey! Guess what Daddy's doing!"

Of course, now they already know the answer and they pretty much roll their eyes at me when I ask, but it's still fun.

Can you guess the answer?

The answer is: "Making money!"

No matter where I am... No matter what time it is... No matter what I'm actually doing at the time... I could be on vacation, at the beach, sitting at my desk, coaching basketball, playing music... it just doesn't matter.

I am making money 24 hours a day, 7 days a week, 365 days a year.

How do I do that? I use AutoResponders to generate, manage, and follow up with my sales leads.

AutoResponders are quickly catching on with online marketers as a "must have" tool for success. And it's easy to see why. They make life and sales much easier.

The simplest way to understand AutoResponders is to think of them as a system that automatically responds to requests for information. You can set up your AutoResponder to send out sales messages, follow-up messages, price updates, training information, special announcements, weekly articles, and more.

My favorite way to use AutoResponders is as my personal sales assistant.

As my advertising works for me around the world and around the clock, I am receiving requests for more information. Some days, it may be a couple of requests here and there. Other days, it can be dozens of requests. I love what I do for a living but the thought of managing and replying to each request one at a time would just be insane.

Instead, I let my AutoResonder handle it. Here's how it works for me:

My websites all have a form that visitors can fill out to request more information from me. When someone fills out my form, my AutoResponder collects their information.

The first thing my AutoResponder does when it receives their information is send a confirmation request to their email address. This protects me from spam complaints and makes sure that the person whose email address is entered in to the form really wants my info.

Once the new prospect confirms that they do want to receive my information, my AutoResponder sends my first sales message out to them. The message is personalized with the prospect's name. This helps my messages get through and helps me build credibility and rapport with my prospects.

From there my AutoResponder will continue sending follow-up messages to my prospects every few days.

The best part about this system is that it's all 100 percent automated. Once I set up my messages, the AutoResponder just handles all my follow-up and list management tasks. All of my sales messages include information on how to order. Most of my customers just place their order directly without ever actually talking to me. Every once in a while, a prospect may email me with a question. It takes me just a moment or two to answer a question when the prospect is already familiar with me and my offer.

My AutoResponder works on autopilot.

I don't have to remember to send a follow-up message.

I don't have to remember which message is next or when.

I don't have to worry about managing the list. If someone wants off my list, they just click a convenient link and they're gone.

Meanwhile, as prospects are responding to my ad, my AutoResponder just keeps working like a little personal sales assistant.

And the best part? My assistant never talks back, never complains, never calls in sick, never asks for a raise, and never forgets to do their job!

Now THAT is what I call a good assistant!

Brian Rooney is the co-founder of TrafficWave.net LLC. TrafficWave.net provides AutoResponder and AdTracking services to thousands of clients from more than 60 countries.

by : Bryan Rooney

The Amazing Money Machine

History has a way of prizing timeless qualities like vision and oratory above temporal things like money. So if Barack Obama becomes our nation’s first black president, civics textbooks will probably never note his fund-raising prowess or the financial challenges he had to overcome simply to compete with the likes of Hillary Clinton. But Obama would not be where he is today if he did not possess a preternatural ability to elicit huge sums. Obama prompts an impulse in people to reach for historical antecedents when describing him—as a speaker, Martin Luther King Jr.; as an inspiration to young voters, Robert F. Kennedy. No one I’m aware of has suggested an apt comparison for Obama, the mighty fund-raiser. But whenever I think about the quarter billion dollars he has raised so far, the image that leaps to mind is Scrooge McDuck diving joyously into his piles of gold.

Also in the June Atlantic:

HisSpace

How would Obama's success in online campaigning translate into governing? By Marc Ambinder


The story of Obama’s success is very much a story about money. It provided his initial credibility. It paid for his impressive campaign operation. It allowed him first to compete with, and then to overwhelm, the most powerful Democratic family in a generation—one that understood the power of money in politics and commanded a network of wealthy donors that has financed the Democratic Party for years.

What’s intriguing to Democrats and worrisome to Republicans is how someone lacking these deep connections to traditional sources of wealth could raise so much money so quickly. How did he do it? The answer is that he built a fund-raising machine quite unlike anything seen before in national politics. Obama’s machine attracts large and small donors alike, those who want to give money and those who want to raise it, veteran activists and first-time contributors, and—especially—anyone who is wired to anything: computer, cell phone, PDA.

Here’s another thing: he is doing it almost effortlessly. That is to say, in an era when the imperative for campaign dollars demands more and more of a politician’s time and lurks behind so many recent scandals (including the auctioning-off of the Lincoln Bedroom), Obama has raised more money than anybody else without plumbing ethical gray areas or even spending much of his own time soliciting donations. During the month of February, for example, his campaign raised a record-setting $55 million—$45 million of it over the Internet—without the candidate himself hosting a single fund-raiser. The money just came rolling in.

Obama’s campaign is admired by insiders of both parties for its functional beauty—not just admired but gawked at, like some futuristic concept car leaking rocket vapor at an auto show. Obama’s campaign has made a similar leap in how it has applied technology to the practices of raising money and organizing, and it is already the clear model for everyone else.

To get a better sense of why it has succeeded, I opted to undergo the full tech immersion while reporting this piece, and soon had Obama ring tones on my phone, new networks of online “friends,” text-message updates from the campaign, and regular e-mails from its manager, all gently encouraging me to give money, volunteer time, bring in new friends, and generally reorient my life in ways that were made to seem hip and fun—and inexorably aimed at the greater glory of Barack Obama. How Obama arrived at this new model for campaigning is a tale of foresight and circumstance, his campaign’s enterprise and his opponent’s shortsightedness, and it has as much to do with Silicon Valley as it does with Washington politics.

Obama is a gifted politician by anyone’s measure, but what distinguishes him from earlier insurgents is his ability to fully harness the excitement that his candidacy has created, in votes and in dollars. Three forces had to come together for this to happen: the effect of campaign-finance laws in broadening the number and types of people who fund the political process; the emergence of Northern California as one of the biggest sources of Democratic money; and the recognition by a few Silicon Valley entrepreneurs and venture capitalists that the technology and business practices they had developed in their day jobs could have a transformative effect on national politics.

A few days after Obama announced his $55 million figure, I went to Silicon Valley to meet some of these people, and to find out how they saw the future coming and got there first.

Mark Gorenberg decided to start fund-raising in earnest during the early days of John Kerry’s presidential campaign, back when Barack Obama was considered merely a comer in Illinois politics. Granted, that was all of five years ago. But it was a different world then, at least in the elite fund-raising circles Gorenberg was entering. Every election cycle, politicians looking for money traveled a well-worn circuit of important donors.

Two big changes had just come about when Kerry got going in 2003. The McCain-Feingold campaign-finance law had taken effect for the first time in a presidential campaign, limiting the large “soft money” donations to political parties that Democrats in particular relied on; for years, they had solicited large donations from corporations and the rich to build the party. Now the only way to raise money was to attract small donors, a task Democrats had never done well. (The law limited individual donations to a presidential candidate to $2,000 for the primary and general elections each in 2004; the limit increased to $2,300 for 2008.) The other important change was the Iraq War, which had energized the Democratic Party.

Gorenberg, a partner in the San Francisco venture-capital firm of Hummer Winblad, was representative of a certain kind of prosperous Northern California Democrat whom the war and the general climate of Bush-administration malfeasance had pushed from casual supporter to committed activist. And he was representative of Silicon Valley, in that he thought in terms of networks. Partly, this was his job: a venture capitalist looking to invest in the next big thing must know everything that is happening and everyone who is making it happen. But everyone else was thinking about networks, too. The Valley was still emerging from the crash of 2001, yet it was already clear that the next boom would be in social-networking entities like MySpace and Facebook, which created vast, interconnected communities on the Web.

Political fund-raising, on the other hand, was stuck in an earlier era. “Take a typical Gore event in 2000,” Goren­berg, an affable and slightly rumpled engineer, told me when I visited his office in a converted brick warehouse on the Embarcadero. “By the time he was the nominee, a fund-raiser might be 20 people in a living room who’d given $100,000 to the party, and 50 to 100 in the backyard at $5,000.”

The engineer in Gorenberg was bothered by the system’s obvious inefficiency. Relying exclusively on the rich put limits on who got involved, and by design the new campaign-finance laws weakened their influence. He had an idea about how networks could help. “If the most that any one person could write a check for was $2,000,” he said, “then the important people suddenly became those who would put their hand up and say, ‘I’ll raise $50,000 or $100,000.’” Ever since Watergate-era campaign-finance laws put limits on the amount that an individual can give to a presidential candidate, “bundlers” who are able to gather many individual checks have been important figures, most recently the “Pioneers” and “Rangers” in George W. Bush’s presidential campaigns. But in the past, everyone tended to draw from the same moneyed crowd.

Gorenberg tapped into his broad network of entrepreneurs and venture capitalists and discovered that many of them were eager to get involved—eager enough not just to give but to tap their own networks to raise money for Kerry. Collectively, these “raisers” generated a great deal of money, and much of it came from new sources, particularly what Gorenberg likes to call the area’s new middle class. “There is a tremendous amount of wealth in Silicon Valley,” John Roos, Obama’s Northern California finance chair and the CEO of the Palo Alto law firm Wilson Sonsini Goodrich & Rosati, told me. “Not just massive individual wealth, but wealth spread collectively among the engineers, lawyers, and executives who made gains in the good years and now have the ability to contribute a $2,300 check without it being a significant hit to them.”

By the end of the 2004 campaign, Gorenberg had surpassed all the old names to become Kerry’s biggest fund-raiser. And for the first time, spurred by these expanding networks, the Bay Area eclipsed Los Angeles as the biggest source of Democratic donations in California.

In Silicon Valley, as elsewhere, Kerry’s loss, while devastating, seemed only to intensify the activist zeal. Goren­berg teamed up with a friend, Nadine North, who recruits executives for tech firms, to pursue a new goal in 2006: helping Democrats win back the House of Representatives.

With guidance from Nancy Pelosi, San Francisco’s reigning power, the pair chose 10 races that looked like good possibilities to help Democrats pick up the 15 seats they needed to regain control. But they worried about how to raise money for a slate of House candidates who lacked the glamour of a presidential nominee. They found their answer in the software industry. After the Internet bubble burst, software companies had been unable to sell expensive systems. Marc Benioff, the CEO of Salesforce.com, hit upon a solution when he dropped the practice of charging full price up front in favor of a subscription model that charged a little at a time for access to software. The idea appealed to companies that lacked the budget or the appetite to write another big check, while the promise of recurring revenue helped reinvigorate the software industry.

North and Gorenberg borrowed the subscription model for their “Win Back the House” project. Instead of asking for a big check up front, as they would for a presidential candidate, they invited each of their House candidates to the Bay Area over the course of the year, so that supporters could give recurrent, but smaller, donations. Most of the donors were from the tech industry, and understood the software-subscription model. They came to enough gatherings, and kept writing enough checks, that the roster of House candidates eventually expanded from 10 to 30. As before, the emphasis was not on writing big checks but on building raiser networks, including people who couldn’t contribute much themselves. By November, North and Gorenberg were among the top Democratic fund-raisers nationwide.

On election night, everyone gathered to watch the returns come in, and this time they experienced a resounding victory: Democrats recaptured the House. “Many of the candidates in the key races were ones we had supported,” North told me. “It really brought the national political landscape home to Democrats in the Bay Area.”

by : Joshua Green